Saturday's meeting at Doncaster, due to feature the Sky Bet Chase, is the latest victim of the current cold snap.
The South Yorkshire track had already abandoned Friday's meeting because of snow earlier in the week and hopes of a thaw were ended after a 2pm inspection on Thursday.
The Champion Hurdle Trial, switched from Haydock, was another quality race scheduled to be staged on the card along with the Lightning Novices' Chase.
Clerk of the course Roderick Duncan said: "We have abandoned due to snow and frost. There's a severe frost forecast for tonight, with temperatures down to minus 4C or minus 5C.
"Temperatures are then not due to rise above zero on Friday with a Met Office warning for further snow on Friday night, so there is no hope."